Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …

The p53 transcription factor is a potent suppressor of tumor growth. We report here an
analysis of its direct transcriptional program using Global Run-On sequencing (GRO-seq) …

Summary Cardiolipin (CL), a mitochondria-specific glycerophospholipid, is required for
diverse mitochondrial processes and orchestrates the function of various death-inducing …

Members of the coiled-coil-helix-coiled-coil-helix (CHCH) domain-containing protein family
that carry (CX 9 C) type motifs are imported into the mitochondrion with the help of the …

Telomerase is the ribonucleoprotein (RNP) enzyme that elongates telomeric DNA to
compensate for the attrition occurring during each cycle of DNA replication. Knowing the …

The transcription factor p53 responds to DNA double-strand breaks by increasing in
concentration in a series of pulses of fixed amplitude, duration, and period. How p53 pulses …

Cancer stem cells (CSC) are considered responsible for tumor initiation, therapeutic
resistance, and metastasis. A comprehensive knowledge of the mechanisms governing the …

Early clinical trials using murine double minute 2 (MDM2) inhibitors demonstrated proof-of-
concept of p53-induced apoptosis by MDM2 inhibition in cancer cells; however, not all wild …