Ultrasound technology, synergistically harnessed with genetic engineering and chemistry
concepts, has started to open the gateway to the remarkable realm of sonogenetics—a …

Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for
noninvasive and selective control of neural activity. It is a promising tool for studying neural …

Abstract The Angiotensin II Type 1 (AT1) receptor is one of the most widely studied GPCRs
within the context of biased signaling. While the AT1 receptor is activated by agonists such …

Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular
membranes or indirectly through their tethered components, provoking cellular …

Our understanding of the role of membrane tension in the field of membrane biophysics is
rapidly evolving from a passive construct to an active player in a variety of cellular …

Many proteins in living cells are subject to mechanical forces, which can be generated
internally by molecular machines, or externally, eg, by pressure gradients. In general, these …

Although coveted in applications, few materials expand when subject to compression or
contract under decompression, ie, exhibit negative compressibility. A key step to achieve …

Membrane-embedded mechanosensitive (MS) proteins, including ion channels and G-
protein coupled receptors (GPCRs), are essential for the transduction of external mechanical …

Mechanosensitive channels of large conductance (MscL) serve as a mechanoelectrical
valve of cells in response to the membrane tension. The influence of membrane …

Mechanical forces are inseparable from most cellular functions. Cell division, contraction,
and adhesion generate intrinsic forces in the cells, whereas perturbations in the …