Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

The lysine‐specific demethylase 6A/UTX (gene name KDM6A) acts as a component of the
COMPASS complex to control gene activation. UTX demethylates H3K27me2/3 at genes …

Breast cancer is the most common cancer and leading cause of cancer death among
women worldwide, encompassing a wide heterogeneity of subtypes with different clinical …

Chemotherapy, targeted therapy, and immunotherapy are effective against most tumors, but
drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 …

Simple Summary Regulation of gene expression is important for appropriate cell
development but can also lead to inappropriate cell transformation resulting in cancer …

Background & Aims Inactivating mutations of KDM6A, a histone demethylase, were
frequently found in pancreatic ductal adenocarcinoma (PDAC). We investigated the role of …

Aberrant epigenetic reprogramming is a major factor of developmental failure of cloned
embryos. Histone H3 lysine 27 trimethylation (H3K27me3), a histone mark for transcriptional …

Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …

Histone demethylases remove transcriptional repressive marks from histones in the nucleus.
KDM6A (also known as UTX) is a lysine demethylase which acts on the trimethylated lysine …