A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

J Peng, M Fan, C An, F Ni, W Huang… - Basic & clinical …, 2022 - Wiley Online Library
Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …

Therapeutic potential of cannabis, cannabidiol, and cannabinoid-based pharmaceuticals

CA Legare, WM Raup-Konsavage, KE Vrana - Pharmacology, 2022 - karger.com
Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

THC and CBD: Similarities and differences between siblings

N Stella - Neuron, 2023 - cell.com
Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021 - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

The role of glutamate receptors in epilepsy

TS Chen, TH Huang, MC Lai, CW Huang - Biomedicines, 2023 - mdpi.com
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

Cannabidiol adverse effects and toxicity

MA Huestis, R Solimini, S Pichini… - Current …, 2019 - ingentaconnect.com
Background: Currently, there is a great interest in the potential medical use of cannabidiol
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD …

Effect of cannabidiol on drop seizures in the Lennox–Gastaut syndrome

O Devinsky, AD Patel, JH Cross… - … England Journal of …, 2018 - Mass Medical Soc
Background Cannabidiol has been used for treatment-resistant seizures in patients with
severe early-onset epilepsy. We investigated the efficacy and safety of cannabidiol added to …

Cannabidiol for neurodegenerative disorders: A comprehensive review

S Bhunia, N Kolishetti, AY Arias, A Vashist… - Frontiers in …, 2022 - frontiersin.org
Despite the significant advances in neurology, the cure for neurodegenerative conditions
remains a formidable task to date. Among various factors arising from the complex etiology …

Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome

O Devinsky, JH Cross, L Laux, E Marsh… - … England Journal of …, 2017 - Mass Medical Soc
Background The Dravet syndrome is a complex childhood epilepsy disorder that is
associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for …