Role of the synergistic interactions of environmental pollutants in the development of cancer
There is a growing awareness that the large number of environmental pollutants we are
exposed to on a daily basis are causing major health problems. Compared to traditional …
exposed to on a daily basis are causing major health problems. Compared to traditional …
Considerations for strategic use of high-throughput transcriptomics chemical screening data in regulatory decisions
Recently, numerous organizations, including governmental regulatory agencies in the US
and abroad, have proposed using data from new approach methodologies (NAMs) for …
and abroad, have proposed using data from new approach methodologies (NAMs) for …
High-throughput transcriptomics platform for screening environmental chemicals
New approach methodologies (NAMs) that efficiently provide information about chemical
hazard without using whole animals are needed to accelerate the pace of chemical risk …
hazard without using whole animals are needed to accelerate the pace of chemical risk …
High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per-and polyfluoroalkyl substances as a platform for relative potency …
A Rowan-Carroll, A Reardon, K Leingartner… - Toxicological …, 2021 - academic.oup.com
Per-and poly-fluoroalkyl substances (PFAS) are widely found in the environment because of
their extensive use and persistence. Although several PFAS are well studied, most lack …
their extensive use and persistence. Although several PFAS are well studied, most lack …
Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons
Neonicotinoid pesticides, originally developed to target the insect nervous system, have
been reported to interact with human receptors and to activate rodent neurons. Therefore …
been reported to interact with human receptors and to activate rodent neurons. Therefore …
Potency ranking of per-and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids
AJF Reardon, A Rowan-Carroll… - Toxicological …, 2021 - academic.oup.com
Per-and polyfluoroalkyl substances (PFAS) are some of the most prominent organic
contaminants in human blood. Although the toxicological implications of human exposure to …
contaminants in human blood. Although the toxicological implications of human exposure to …
Per-and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids
GC Addicks, A Rowan-Carroll… - Toxicological …, 2023 - academic.oup.com
Per-and polyfluoroalkyl substances (PFAS) are a wide range of chemicals that are used in a
variety of consumer and industrial products leading to direct human exposure. Many PFAS …
variety of consumer and industrial products leading to direct human exposure. Many PFAS …
Technology transfer of the microphysiological systems: a case study of the human proximal tubule tissue chip
The adoption of a new technology into basic research, and industrial and clinical settings
requires rigorous testing to build confidence in the reproducibility, reliability, robustness, and …
requires rigorous testing to build confidence in the reproducibility, reliability, robustness, and …
High-Throughput Transcriptomics screen of ToxCast chemicals in U-2 OS cells
JL Bundy, LJ Everett, JD Rogers, J Nyffeler… - Toxicology and applied …, 2024 - Elsevier
New approach methodologies (NAMs) aim to accelerate the pace of chemical risk
assessment while simultaneously reducing cost and dependency on animal studies. High …
assessment while simultaneously reducing cost and dependency on animal studies. High …
A RISK-BASED PRIORITIZATION OF PFAS USING PHENOTYPIC AND TRANSCRIPTOMIC DATA FROM HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED …
Per-and polyfluoroalkyl substances (PFAS) are chemicals with important applications; they
are persistent in the environment and may pose human health hazards. Regulatory …
are persistent in the environment and may pose human health hazards. Regulatory …