Role of the synergistic interactions of environmental pollutants in the development of cancer

FA Lagunas‐Rangel, JV Linnea‐Niemi, B Kudłak… - …, 2022 - Wiley Online Library
There is a growing awareness that the large number of environmental pollutants we are
exposed to on a daily basis are causing major health problems. Compared to traditional …

Considerations for strategic use of high-throughput transcriptomics chemical screening data in regulatory decisions

J Harrill, I Shah, RW Setzer, D Haggard… - Current opinion in …, 2019 - Elsevier
Recently, numerous organizations, including governmental regulatory agencies in the US
and abroad, have proposed using data from new approach methodologies (NAMs) for …

High-throughput transcriptomics platform for screening environmental chemicals

JA Harrill, LJ Everett, DE Haggard… - Toxicological …, 2021 - academic.oup.com
New approach methodologies (NAMs) that efficiently provide information about chemical
hazard without using whole animals are needed to accelerate the pace of chemical risk …

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per-and polyfluoroalkyl substances as a platform for relative potency …

A Rowan-Carroll, A Reardon, K Leingartner… - Toxicological …, 2021 - academic.oup.com
Per-and poly-fluoroalkyl substances (PFAS) are widely found in the environment because of
their extensive use and persistence. Although several PFAS are well studied, most lack …

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

D Loser, MG Hinojosa, J Blum, J Schaefer, M Brüll… - Archives of …, 2021 - Springer
Neonicotinoid pesticides, originally developed to target the insect nervous system, have
been reported to interact with human receptors and to activate rodent neurons. Therefore …

Potency ranking of per-and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids

AJF Reardon, A Rowan-Carroll… - Toxicological …, 2021 - academic.oup.com
Per-and polyfluoroalkyl substances (PFAS) are some of the most prominent organic
contaminants in human blood. Although the toxicological implications of human exposure to …

Per-and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids

GC Addicks, A Rowan-Carroll… - Toxicological …, 2023 - academic.oup.com
Per-and polyfluoroalkyl substances (PFAS) are a wide range of chemicals that are used in a
variety of consumer and industrial products leading to direct human exposure. Many PFAS …

Technology transfer of the microphysiological systems: a case study of the human proximal tubule tissue chip

C Sakolish, EJ Weber, EJ Kelly, J Himmelfarb… - Scientific reports, 2018 - nature.com
The adoption of a new technology into basic research, and industrial and clinical settings
requires rigorous testing to build confidence in the reproducibility, reliability, robustness, and …

High-Throughput Transcriptomics screen of ToxCast chemicals in U-2 OS cells

JL Bundy, LJ Everett, JD Rogers, J Nyffeler… - Toxicology and applied …, 2024 - Elsevier
New approach methodologies (NAMs) aim to accelerate the pace of chemical risk
assessment while simultaneously reducing cost and dependency on animal studies. High …

A RISK-BASED PRIORITIZATION OF PFAS USING PHENOTYPIC AND TRANSCRIPTOMIC DATA FROM HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED …

HHD Tsai, LC Ford, Z Chen, AN Dickey, FA Wright… - Altex, 2024 - pmc.ncbi.nlm.nih.gov
Per-and polyfluoroalkyl substances (PFAS) are chemicals with important applications; they
are persistent in the environment and may pose human health hazards. Regulatory …