Antimicrobial peptides: from design to clinical application

C Zhang, M Yang - Antibiotics, 2022 - mdpi.com
Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus
aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum …

Antimicrobial peptides: potential application in liver cancer

C Zhang, M Yang, AC Ericsson - Frontiers in microbiology, 2019 - frontiersin.org
The physicochemical properties of antimicrobial peptides (AMPs) including size, net charge,
amphipathic structure, hydrophobicity, and mode-of-action together determine their broad …

Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol

M Yang, X Qi, N Li, JT Kaifi, S Chen, AA Wheeler… - Nature …, 2023 - nature.com
The interplay between western diet and gut microbiota drives the development of non-
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …

Benefit of Dietary Supplementation with Bacillus subtilis BYS2 on Growth Performance, Immune Response, and Disease Resistance of Broilers

Y Dong, R Li, Y Liu, L Ma, J Zha, X Qiao, T Chai… - Probiotics and …, 2020 - Springer
A strain of Bacillus subtilis (B. subtilis) BYS2 was previously isolated from Mount Tai, which
is located in Tai'an City in the Shandong Province of China. The strain was then stored in the …

The ancestral N-terminal domain of big defensins drives bacterially triggered assembly into antimicrobial nanonets

K Loth, A Vergnes, C Barreto, SN Voisin, H Meudal… - MBio, 2019 - Am Soc Microbiol
Big defensins, ancestors of β-defensins, are composed of a β-defensin-like C-terminal
domain and a globular hydrophobic ancestral N-terminal domain. This unique structure is …

Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

M Yang, C Zhang, MZ Zhang, S Zhang - BMC microbiology, 2018 - Springer
Abstract Background Avian β-defensins (AvBD) are cationic antimicrobial peptides (CAMP)
with broad-spectrum antimicrobial activity, chemotactic property, and low host cytotoxicity …

[HTML][HTML] Evolutionary diversification of defensins and cathelicidins in birds and primates

A van Dijk, R Guabiraba, G Bailleul, C Schouler… - Molecular …, 2023 - Elsevier
Divergent evolution for more than 310 million years has resulted in an avian immune system
that is complex and more compact than that of primates, sharing much of its structure and …

Avian antimicrobial peptides: in vitro and in ovo characterization and protection from early chick mortality caused by yolk sac infection

TTT Nguyen, B Allan, C Wheler, W Köster, V Gerdts… - Scientific Reports, 2021 - nature.com
Increasing antibiotic resistance is a matter of grave concern for consumers, public health
authorities, farmers, and researchers. Antimicrobial peptides (AMPs) are emerging as novel …

The role and potential application of antimicrobial peptides in autoimmune diseases

C Zhang, M Yang - Frontiers in immunology, 2020 - frontiersin.org
Most of the antimicrobial peptides (AMPs) are small, cationic, and amphipathic peptides
with< 50 amino acids (1), which are also known as host defense peptides (HDPs). As listed …

Effects of oral administration of Lactobacillus reuteri on mucosal barrier function in the digestive tract of broiler chicks

T Nii, J Jaisue, N Isobe, Y Yoshimura - The journal of Poultry Science, 2020 - jstage.jst.go.jp
Probiotic bacteria are known for their beneficial effects on the intestinal immune function of
the host animal. However, their effects on mucosal barrier function in chicks are not …