Prolonged elevated oxidative stress (OS) possesses negative effect on cell structure and
functioning, and is associated with the development of numerous disorders. Naturally …

Cisplatin is a highly effective chemotherapeutic agent that has been used for more than 50
years for a variety of cancers; however, its use is limited by toxicity, including nephrotoxicity …

Background: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-
induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation …

Introduction Cisplatin-induced nephrotoxicity (CIN) can be prevented by fluid hydration,
electrolyte supplementation, or forced diuresis; however, the best way to prevent CIN is still …

Despite constant achievements in treatment, acute kidney injury (AKI) remains a significant
public health problem and a cause of mortality in the human population. In developed …

Background: Cisplatin, a platinum complex discovered by Rosenberg in 1969, has long
been known as the first metal-based anticancer agent. Since then, various similar …

Cisplatin-induced acute kidney injury (AKI) is a clinical disease characterized by a sudden
loss of renal function within a few hours or days, due to cisplatin uptake. Fulvestrant is an …

Nephropathy and nephrotoxicity are significant causes of renal impairment, with both
conditions contributing to a substantial global healthcare burden. Nephropathy …

Gastric cancer is a commonly diagnosed form of cancer, and cisplatin is commonly used as
a chemotherapy drug for treating it. However, the side effects of cisplatin may reduce …

The main obstacle to cisplatin's efficacy in cancer chemotherapy is neurotoxicity. The
objective of this study was to create and characterize amifostine (AMF)-loaded silica …