Loss of skeletal muscle mass and strength has recently become a hot research topic with the
extension of life span and an increasingly sedentary lifestyle in modern society …

Inflammatory myopathies, collectively known as myositis, are heterogeneous disorders
characterised by muscle inflammation, and frequently accompanied by extramuscular …

Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and
degradation. Excessive ECM deposition results in scarring and thickening of the affected …

Inclusion body myositis (IBM) is often viewed as an enigmatic disease with uncertain
pathogenic mechanisms and confusion around diagnosis, classification and prospects for …

BACKGROUND Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in
their function leading to decreased insulin secretion or may arise from insulin resistance and …

Physical inactivity, sarcopenia, and frailty are highly prevalent, independent predictors of
morbidity and mortality in patients with cirrhosis. Across a range of chronic diseases …

Experimental research has recognized the importance of cardiac fibroblast and
myofibroblast cells in heart repair and function. In a normal healthy heart, the cardiac …

Inclusion body myositis (IBM) is a progressive muscle disease affecting patients over the
age of 40, with distinctive clinical and histopathological features. The typical clinical …

Since the publication of the 2013 European Neuromuscular Center (ENMC) diagnostic
criteria for Inclusion Body Myositis (IBM), several advances have been made regarding IBM …

Chronic kidney disease (CKD), a chronic catabolic condition, is characterized by muscle
wasting and decreased muscle endurance. Many insights into the molecular mechanisms of …