The S-adenosylmethionine-dependent methyltransferase enzymes share little sequence
identity, but incorporate a highly conserved structural fold. Surprisingly, residues that bind …

To date, about 90 post-transcriptional modifications have been reported in tRNA expanding
their chemical and functional diversity. Methylation is the most frequent post-transcriptional …

RNA metabolism, broadly defined as the compendium of all processes that involve RNA,
including transcription, processing and modification of transcripts, translation, RNA …

In human mitochondria, 1-methyladenosine (m1A) occurs at position 58 of tRNALeu (UUR).
In addition, partial m1A58 modifications have been found in human mitochondrial tRNALys …

tRNA modifications are crucial for efficient and accurate protein translation, with defects
often linked to disease. There are 7 cytoplasmic tRNA modifications in the yeast …

Among all types of RNA, tRNA is unique given that it possesses the largest assortment and
abundance of modified nucleosides. The methylation at N1 of adenosine 58 is a conserved …

S-Adenosylmethionine synthetase (MAT) catalyzes formation of S-adenosylmethionine
(SAM) from ATP and l-methionine (Met) and hydrolysis of tripolyphosphate to PPi and Pi …

Recent analyses identified a putative catalytic tetrad KDKE common to several families of
site-specific methyltransferases (MTases) that modify 2′-hydroxyl groups of ribose in …

Abstract N 1‐methyladenosine (m1A) is found at position 58 in the T‐loop of many tRNAs. In
yeast, the formation of this modified nucleoside is catalyzed by the essential tRNA (m1A58) …

The modified nucleoside 1‐methyladenosine (m1A) is found in the T‐loop of many tRNAs
from organisms belonging to the three domains of life (Eukaryota, Bacteria, Archaea). In the …