[HTML][HTML] Current treatment paradigms and emerging therapies for NAFLD/NASH
Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …
Mesenchymal stem cells
Stem cells have two features: the ability to differentiate along different lineages and the
ability of self-renewal. Two major types of stem cells have been described, namely …
ability of self-renewal. Two major types of stem cells have been described, namely …
Tendon injury and tendinopathy: healing and repair
Tendon Injury and Tendinopathy: Healing and Repair : JBJS Tendon Injury and Tendinopathy:
Healing and Repair : JBJS JBJS Journal Case Connector Reviews JBJS.org Surgical …
Healing and Repair : JBJS JBJS Journal Case Connector Reviews JBJS.org Surgical …
[HTML][HTML] Current efforts and trends in the treatment of NASH
Of all the aspects of non-alcoholic fatty liver disease (NAFLD), the slowest advances have
occurred in the therapeutic field. Thirty-five years after its formal description and after 15 …
occurred in the therapeutic field. Thirty-five years after its formal description and after 15 …
The PPARs: from orphan receptors to drug discovery
Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated …
Several lines of evidence suggest that common diseases of modern society are associated …
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
Inflammatory mediators have the potential to impact a surprising range of diseases,
including obesity and its associated metabolic syndrome. In this paper, we show that the …
including obesity and its associated metabolic syndrome. In this paper, we show that the …
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a …
H Bays, L Mandarino… - The Journal of Clinical …, 2004 - academic.oup.com
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle
and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte …
and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte …
Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis
A Rebbapragada, H Benchabane… - … and cellular biology, 2003 - Am Soc Microbiol
Myostatin, a transforming growth factor β (TGF-β) family member, is a potent negative
regulator of skeletal muscle growth. In this study we characterized the myostatin signal …
regulator of skeletal muscle growth. In this study we characterized the myostatin signal …
The adipoinsular axis: effects of leptin on pancreatic β-cells
TJ Kieffer, JF Habener - American Journal of Physiology …, 2000 - journals.physiology.org
The prevalence of obesity and related diabetes mellitus is increasing worldwide. Here we
review evidence for the existence of an adipoinsular axis, a dual hormonal feedback loop …
review evidence for the existence of an adipoinsular axis, a dual hormonal feedback loop …
PPARγ, the ultimate thrifty gene
J Auwerx - Diabetologia, 1999 - Springer
The peroxisome proliferator-activated receptor gamma (PPAR γ) quickly evolved over the
last decade from a new orphan receptor to one of the best characterized nuclear receptors …
last decade from a new orphan receptor to one of the best characterized nuclear receptors …