[HTML][HTML] Current treatment paradigms and emerging therapies for NAFLD/NASH

S Raza, S Rajak, A Upadhyay, A Tewari… - Frontiers in bioscience …, 2021 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …

Mesenchymal stem cells

DC Ding, WC Shyu, SZ Lin - Cell transplantation, 2011 - journals.sagepub.com
Stem cells have two features: the ability to differentiate along different lineages and the
ability of self-renewal. Two major types of stem cells have been described, namely …

Tendon injury and tendinopathy: healing and repair

P Sharma, N Maffulli - JBJS, 2005 - journals.lww.com
Tendon Injury and Tendinopathy: Healing and Repair : JBJS Tendon Injury and Tendinopathy:
Healing and Repair : JBJS JBJS Journal Case Connector Reviews JBJS.org Surgical …

[HTML][HTML] Current efforts and trends in the treatment of NASH

V Ratziu, Z Goodman, A Sanyal - Journal of hepatology, 2015 - Elsevier
Of all the aspects of non-alcoholic fatty liver disease (NAFLD), the slowest advances have
occurred in the therapeutic field. Thirty-five years after its formal description and after 15 …

The PPARs: from orphan receptors to drug discovery

TM Willson, PJ Brown, DD Sternbach… - Journal of medicinal …, 2000 - ACS Publications
Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated …

IL-17 regulates adipogenesis, glucose homeostasis, and obesity

LA Zúñiga, WJ Shen, B Joyce-Shaikh… - The Journal of …, 2010 - journals.aai.org
Inflammatory mediators have the potential to impact a surprising range of diseases,
including obesity and its associated metabolic syndrome. In this paper, we show that the …

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a …

H Bays, L Mandarino… - The Journal of Clinical …, 2004 - academic.oup.com
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle
and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte …

Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis

A Rebbapragada, H Benchabane… - … and cellular biology, 2003 - Am Soc Microbiol
Myostatin, a transforming growth factor β (TGF-β) family member, is a potent negative
regulator of skeletal muscle growth. In this study we characterized the myostatin signal …

The adipoinsular axis: effects of leptin on pancreatic β-cells

TJ Kieffer, JF Habener - American Journal of Physiology …, 2000 - journals.physiology.org
The prevalence of obesity and related diabetes mellitus is increasing worldwide. Here we
review evidence for the existence of an adipoinsular axis, a dual hormonal feedback loop …

PPARγ, the ultimate thrifty gene

J Auwerx - Diabetologia, 1999 - Springer
The peroxisome proliferator-activated receptor gamma (PPAR γ) quickly evolved over the
last decade from a new orphan receptor to one of the best characterized nuclear receptors …