AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Thyroid hormone (TH) is required for normal development as well as regulating metabolism
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …

Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Obesity is gaining acceptance as a serious primary health burden that impairs the quality of
life because of its associated complications, including diabetes, cardiovascular diseases …

AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …

Thyroid dysfunction and diabetes mellitus are closely linked. Several studies have
documented the increased prevalence of thyroid disorders in patients with diabetes mellitus …

Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to
its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …