Animal models of Parkinson's disease: Bridging the gap between disease hallmarks and research questions
A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration
Age-related neurodegenerative diseases involving amyloid aggregation remain one of the
biggest challenges of modern medicine. Alterations in the gastrointestinal microbiome play …
biggest challenges of modern medicine. Alterations in the gastrointestinal microbiome play …
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
SG Chen, V Stribinskis, MJ Rane, DR Demuth… - Scientific reports, 2016 - nature.com
Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-
like transmission of protein aggregation. Factors responsible for the initiation of AS …
like transmission of protein aggregation. Factors responsible for the initiation of AS …
[HTML][HTML] The function of α-synuclein
JT Bendor, TP Logan, RH Edwards - Neuron, 2013 - cell.com
Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
Aggregated forms of α-synuclein constitute the major component of Lewy bodies, the
proteinaceous aggregates characteristic of Parkinson's disease. Emerging evidence …
proteinaceous aggregates characteristic of Parkinson's disease. Emerging evidence …
Human Hsp70 disaggregase reverses Parkinson's-linked α-synuclein amyloid fibrils
Intracellular amyloid fibrils linked to neurodegenerative disease typically accumulate in an
age-related manner, suggesting inherent cellular capacity for counteracting amyloid …
age-related manner, suggesting inherent cellular capacity for counteracting amyloid …
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
The self-assembly of α-synuclein is closely associated with Parkinson's disease and related
syndromes. We show that squalamine, a natural product with known anticancer and antiviral …
syndromes. We show that squalamine, a natural product with known anticancer and antiviral …
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …
model organism for understanding molecular mechanisms of human diseases. Many basic …