A catalog of GWAS fine-map** efforts in autoimmune disease
Genome-wide association studies (GWASs) have enabled unbiased identification of genetic
loci contributing to common complex diseases. Because GWAS loci often harbor many …
loci contributing to common complex diseases. Because GWAS loci often harbor many …
CD58 Immunobiology at a Glance
Y Zhang, Q Liu, S Yang, Q Liao - Frontiers in immunology, 2021 - frontiersin.org
The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a
costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand …
costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand …
SNPs in sites for DNA methylation, transcription factor binding, and miRNA targets leading to allele-specific gene expression and contributing to complex disease risk …
Introduction: The complex genetic diversity among human populations results from an
assortment of factors acting at various sequential levels, including mutations, population …
assortment of factors acting at various sequential levels, including mutations, population …
Methods for functional characterization of genetic polymorphisms of non-coding regulatory regions of the human genome
Currently, numerous associations between genetic polymorphisms and various diseases
have been characterized through the Genome-Wide Association Studies. Majority of the …
have been characterized through the Genome-Wide Association Studies. Majority of the …
EGR1 and RXRA transcription factors link TGF-β pathway and CCL2 expression in triple negative breast cancer cells
Transforming growth factor beta (TGF-β) is the main cytokine responsible for the induction of
the epithelial-mesenchymal transition of breast cancer cells, which is a hallmark of tumor …
the epithelial-mesenchymal transition of breast cancer cells, which is a hallmark of tumor …
Genome-wide DNA methylation profiling identifies epigenetic changes in CD4+ and CD14+ cells of multiple sclerosis patients
Multiple sclerosis (MS) is a chronic autoimmune and degenerative disease of the central
nervous system, which develops in genetically predisposed individuals upon exposure to …
nervous system, which develops in genetically predisposed individuals upon exposure to …
[HTML][HTML] Minor C allele of the SNP rs7873784 associated with rheumatoid arthritis and type-2 diabetes mellitus binds PU. 1 and enhances TLR4 expression.
Abstract Toll-like receptor 4 (TLR4) is an innate immunity receptor predominantly expressed
on myeloid cells and involved in the development of various diseases, many of them with …
on myeloid cells and involved in the development of various diseases, many of them with …
Functional genomics of autoimmune diseases
A Suzuki, MM Guerrini, K Yamamoto - Annals of the Rheumatic …, 2021 - ard.bmj.com
For more than a decade, genome-wide association studies have been applied to
autoimmune diseases and have expanded our understanding on the pathogeneses …
autoimmune diseases and have expanded our understanding on the pathogeneses …
The Risk G Allele of the Single-Nucleotide Polymorphism rs928413 Creates a CREB1-Binding Site That Activates IL33 Promoter in Lung Epithelial Cells
Cytokine interleukin 33 (IL-33) is constitutively expressed by epithelial barrier cells, and
promotes the development of humoral immune responses. Along with other proinflammatory …
promotes the development of humoral immune responses. Along with other proinflammatory …
[HTML][HTML] Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs
XF Chen, MR Guo, YY Duan, F Jiang, H Wu, SS Dong… - JCI insight, 2020 - ncbi.nlm.nih.gov
More than 90% of autoimmune-associated variants are located in noncoding regions,
leading to challenges in deciphering the underlying causal roles of functional variants and …
leading to challenges in deciphering the underlying causal roles of functional variants and …