Role of skeletal muscle in insulin resistance and glucose uptake
KE Merz, DC Thurmond - Comprehensive Physiology, 2011 - Wiley Online Library
The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …
[HTML][HTML] Immunobiology of inherited muscular dystrophies
The immune response to acute muscle damage is important for normal repair. However, in
chronic diseases such as many muscular dystrophies, the immune response can amplify …
chronic diseases such as many muscular dystrophies, the immune response can amplify …
[HTML][HTML] p38 MAPKs—roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets
CM Brennan, CP Emerson Jr, J Owens, N Christoforou - JCI insight, 2021 - ncbi.nlm.nih.gov
Abstract p38 MAPKs play a central role in orchestrating the cellular response to stress and
inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have …
inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have …
Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies
JR Terrill, HG Radley‐Crabb, T Iwasaki… - The FEBS …, 2013 - Wiley Online Library
The muscular dystrophies comprise more than 30 clinical disorders that are characterized by
progressive skeletal muscle wasting and degeneration. Although the genetic basis for many …
progressive skeletal muscle wasting and degeneration. Although the genetic basis for many …
[HTML][HTML] Interplay between mitochondrial reactive oxygen species, oxidative stress and hypoxic adaptation in facioscapulohumeral muscular dystrophy: Metabolic …
P Heher, M Ganassi, A Weidinger, EN Engquist… - Redox biology, 2022 - Elsevier
Facioscapulohumeral muscular dystrophy (FSHD) is characterised by descending skeletal
muscle weakness and wasting. FSHD is caused by mis-expression of the transcription factor …
muscle weakness and wasting. FSHD is caused by mis-expression of the transcription factor …
Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7
CRS Banerji, PS Zammit - EMBO molecular medicine, 2021 - embopress.org
Facioscapulohumeral muscular dystrophy (FSHD) is characterised by progressive skeletal
muscle weakness and wasting. FSHD is linked to epigenetic derepression of the …
muscle weakness and wasting. FSHD is linked to epigenetic derepression of the …
DUX4 role in normal physiology and in FSHD muscular dystrophy
E Mocciaro, V Runfola, P Ghezzi, M Pannese… - Cells, 2021 - mdpi.com
In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4)
has gone from being an obscure entity to being a key factor in important physiological and …
has gone from being an obscure entity to being a key factor in important physiological and …
Facioscapulohumeral muscular dystrophy: genetics, gene activation and downstream signalling with regard to recent therapeutic approaches: an update
Whilst a disease-modifying treatment for Facioscapulohumeral muscular dystrophy (FSHD)
does not exist currently, recent advances in complex molecular pathophysiology studies of …
does not exist currently, recent advances in complex molecular pathophysiology studies of …
A human pluripotent stem cell model of facioscapulohumeral muscular dystrophy-affected skeletal muscles
Facioscapulohumeral muscular dystrophy (FSHD) represents a major unmet clinical need
arising from the progressive weakness and atrophy of skeletal muscles. The dearth of …
arising from the progressive weakness and atrophy of skeletal muscles. The dearth of …
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy
Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of DUX4 in
skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated …
skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated …