Once damaged, articular cartilage has very little capacity for spontaneous healing because
of the avascular nature of the tissue. Although many repair techniques have been proposed …

Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

Studies in animal models of osteoarthritis (OA) have been used extensively to gain insight
into the pathogenesis of OA, but early studies largely ignored inflammation except as a …

Objective. This study explored the therapeutic effect of interleukin‐1 receptor antagonist (IL‐
1Ra), administered by gene transfer, on the progression of osteoarthritic (OA) lesions in an …

Novel approaches to treat osteoarthritis are required and progress in understanding the
biology of cartilage disorders has led to the use of genes whose products stimulate cartilage …

The availability of genetically altered cells is an essential prerequisite for many scientific and
therapeutic applications including functional genomics, drug development, and gene …

Objective Muscle‐derived stem cells (MDSCs) isolated from mouse skeletal muscle exhibit
long‐time proliferation, high self‐renewal, and multipotent differentiation. This study was …

Objective The differentiation of mesenchymal stem cells (MSCs) into chondrocytes provides
an attractive basis for the repair and regeneration of articular cartilage. Under clinical …

Research using animal models provides important knowledge of pathological conditions
that even tually can lead to the development of more effective clinical treatment of diseases …

Articular cartilage lesions are a commonly encountered medical problem, for which there
exists no satisfactory solution at present. Although many treatment protocols are in current …