[HTML][HTML] A comprehensive overview of the complex world of the endo-and sarcoplasmic reticulum Ca2+-leak channels

FO Lemos, G Bultynck, JB Parys - … et Biophysica Acta (BBA)-Molecular Cell …, 2021 - Elsevier
Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

[HTML][HTML] Nothing regular about the regulins: Distinct functional properties of SERCA transmembrane peptide regulatory subunits

N Rathod, JJ Bak, JO Primeau, MLE Fisher… - International Journal of …, 2021 - mdpi.com
The sarco-endoplasmic reticulum calcium ATPase (SERCA) is responsible for maintaining
calcium homeostasis in all eukaryotic cells by actively transporting calcium from the cytosol …

The role of micropeptides in biology

R Vitorino, S Guedes, F Amado, M Santos… - Cellular and Molecular …, 2021 - Springer
Micropeptides are small polypeptides coded by small open-reading frames. Progress in
computational biology and the analyses of large-scale transcriptomes and proteomes have …

Targeting calcium regulators as therapy for heart failure: Focus on the sarcoplasmic reticulum Ca-ATPase pump

C Kho - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Impaired myocardial Ca2+ cycling is a critical contributor to the development of heart failure
(HF), causing changes in the contractile function and structure remodeling of the heart …

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

MLE Fisher, E Bovo, R Aguayo-Ortiz, EE Cho… - Elife, 2021 - elifesciences.org
The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-
relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by the inhibitor …

Linking biochemical and structural states of SERCA: achievements, challenges, and new opportunities

R Aguayo-Ortiz, LM Espinoza-Fonseca - International Journal of …, 2020 - mdpi.com
Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase
family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the …

The hidden world of membrane microproteins

CA Makarewich - Experimental cell research, 2020 - Elsevier
Proteins are critical components of biological membranes and play key roles in many
essential cellular processes. Membrane proteins are a structurally and functionally diverse …

Interaction of DWORF with SERCA and PLB as determined by EPR spectroscopy

MD Rustad, O Roopnarine, RL Cornea… - … and biophysical research …, 2023 - Elsevier
Insufficient sarco/endoplasmic reticulum calcium ATPase (SERCA) activity significantly
contributes to heart failure, which is a leading cause of death worldwide. A characteristic …

The transmembrane peptide DWORF activates SERCA2a via dual mechanisms

A Li, SL Yuen, DR Stroik, E Kleinboehl… - Journal of Biological …, 2021 - ASBMB
The Ca-ATPase isoform 2a (SERCA2a) pumps cytosolic Ca 2+ into the sarcoplasmic
reticulum (SR) of cardiac myocytes, enabling muscle relaxation during diastole. Abnormally …

Functional characterization of long noncoding RNAs

JB Moore IV, S Uchida - Current opinion in cardiology, 2020 - journals.lww.com
Functional characterization of long noncoding RNAs : Current Opinion in Cardiology
Functional characterization of long noncoding RNAs : Current Opinion in Cardiology Log in …