HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment
C Eggers, G Arendt, K Hahn, IW Husstedt… - Journal of …, 2017 - Springer
The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …
considerably lowered the incidence of opportunistic infections. With the exception of the …
HIV reservoirs: what, where and how to target them
One of the main challenges in the fight against HIV infection is to develop strategies that are
able to eliminate the persistent viral reservoir that harbours integrated, replication-competent …
able to eliminate the persistent viral reservoir that harbours integrated, replication-competent …
Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19
Objective To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: a cross-sectional study
M Gisslén, RW Price, U Andreasson, N Norgren… - …, 2016 - thelancet.com
Background Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …
Tissue reservoirs of HIV
JK Wong, SA Yukl - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …
characteristics, underscores the importance of studying tissue reservoirs in the development …
HIV-associated neurocognitive disorder
Neurological involvement in HIV is often associated with cognitive impairment. Although
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …
HIV infects astrocytes in vivo and egresses from the brain to the periphery
V Lutgen, SD Narasipura, HJ Barbian… - PLoS …, 2020 - journals.plos.org
HIV invades the brain during acute infection. Yet, it is unknown whether long-lived infected
brain cells release productive virus that can egress from the brain to re-seed peripheral …
brain cells release productive virus that can egress from the brain to re-seed peripheral …
Controversies in HIV-associated neurocognitive disorders
Cross-sectional studies show that around half of individuals infected with HIV-1 have some
degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence …
degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence …
Neuropathogenesis of HIV: from initial neuroinvasion to HIV-associated neurocognitive disorder (HAND)
Z Zayyad, S Spudich - Current Hiv/Aids Reports, 2015 - Springer
Early in the HIV epidemic, the central nervous system (CNS) was recognized as a target of
infection and injury in the advanced stages of disease. Though the most severe forms of HIV …
infection and injury in the advanced stages of disease. Though the most severe forms of HIV …
Monocyte/macrophages and their role in HIV neuropathogenesis
Neurological sequelae of human immunodeficiency virus (HIV) infection have been and
remain a significant problem. Monocytes and macrophages in humans and monkeys are …
remain a significant problem. Monocytes and macrophages in humans and monkeys are …