Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation
Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …
that affects 50 million individuals globally. Because approximately one-third of patients with …
Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?
Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …
caused by a primary brain injury that occurred a long time before the appearance of …
Hilar mossy cells of the dentate gyrus: a historical perspective
The circuitry of the dentate gyrus (DG) of the hippocampus is unique compared to other
hippocampal subfields because there are two glutamatergic principal cells instead of one …
hippocampal subfields because there are two glutamatergic principal cells instead of one …
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy
Reduced hippocampal GABAergic inhibition is acknowledged to be associated with
epilepsy. However, there are no studies that had quantitatively compared the loss of various …
epilepsy. However, there are no studies that had quantitatively compared the loss of various …
Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus
Cyclooxygenase-2 (COX-2), a source of inflammatory mediators and a multifunctional
neuronal modulator, is rapidly induced in select populations of cortical neurons after status …
neuronal modulator, is rapidly induced in select populations of cortical neurons after status …
GABAergic interneurons in epilepsy: More than a simple change in inhibition
The pathophysiology of epilepsy has been historically grounded on hyperexcitability
attributed to the oversimplified imbalance between excitation (E) and inhibition (I) in the …
attributed to the oversimplified imbalance between excitation (E) and inhibition (I) in the …
Neuropeptides as targets for the development of anticonvulsant drugs
E Clynen, A Swijsen, M Raijmakers, G Hoogland… - Molecular …, 2014 - Springer
Epilepsy is a common neurological disorder characterized by recurrent seizures. These
seizures are due to abnormal excessive and synchronous neuronal activity in the brain …
seizures are due to abnormal excessive and synchronous neuronal activity in the brain …
Hilar interneuron vulnerability distinguishes aged rats with memory impairment
Hippocampal interneuron populations are reportedly vulnerable to normal aging. The
relationship between interneuron network integrity and age‐related memory impairment …
relationship between interneuron network integrity and age‐related memory impairment …
Localized delivery of fibroblast growth factor–2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model
A loss of neurons is observed in the hippocampus of many patients with epilepsies of
temporal lobe origin. It has been hypothesized that damage limitation or repair, for example …
temporal lobe origin. It has been hypothesized that damage limitation or repair, for example …
Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy
W Zhang, R Yamawaki, X Wen, J Uhl, J Diaz… - Journal of …, 2009 - jneurosci.org
In temporal lobe epilepsy, seizures initiate in or near the hippocampus, which frequently
displays loss of neurons, including inhibitory interneurons. It is unclear whether surviving …
displays loss of neurons, including inhibitory interneurons. It is unclear whether surviving …