Analysis of big data by machine learning offers considerable advantages for assimilation
and evaluation of large amounts of complex health-care data. However, to effectively use …

Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

Importance Nonrandomized studies using insurance claims databases can be analyzed to
produce real-world evidence on the effectiveness of medical products. Given the lack of …

Abstract These European Resuscitation Council Ethics guidelines provide evidence-based
recommendations for the ethical, routine practice of resuscitation and end-of-life care of …

Real-world studies have become increasingly important in providing evidence of treatment
effectiveness in clinical practice. While randomized clinical trials (RCTs) are the “gold …

Sample size determination is an essential step in planning a clinical study. It is critical to
understand that different study designs need different methods of sample size estimation …

Large language models (LLMs) hold great promise in summarizing medical evidence. Most
recent studies focus on the application of proprietary LLMs. Using proprietary LLMs …

Background In our institute in Marseille, France, we initiated early and massive screening for
coronavirus disease 2019 (COVID-19). Hospitalization and early treatment with …

Abstract Randomized Controlled Trials (RCTs) are increasingly popular in the social
sciences, not only in medicine. We argue that the lay public, and sometimes researchers, put …

Evidence for Health Decision Making — Beyond Randomized, Controlled Trials | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …