Inversions are structural mutations that reverse the sequence of a chromosome segment
and reduce the effective rate of recombination in the heterozygous state. They play a major …

Cis-regulatory sequences, such as enhancers and promoters, control development and
physiology by regulating gene expression. Mutations that affect the function of these …

Long-read sequencing is driving rapid progress in genome assembly across all major
groups of life, including species of the family Drosophilidae, a longtime model system for …

Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Many genomes have been sequenced to high-quality draft status using Sanger capillary
electrophoresis and/or newer short-read sequence data and whole genome assembly …

Over the past 10 years, the development of chromosome conformation capture (3C)
technology and the subsequent genomic variants thereof have enabled the analysis of …

Abstract MicroRNAs (miRNAs) are∼ 22-nucleotide endogenous RNAs that often repress the
expression of complementary messenger RNAs. In animals, miRNAs derive from …

Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion
channels present in animals, plants, and bacteria, which are best characterized for their …

The association of genetic variation with disease and drug response, and improvements in
nucleic acid technologies, have given great optimism for the impact of 'genomic medicine' …

Comparative analysis of multiple genomes in a phylogenetic framework dramatically
improves the precision and sensitivity of evolutionary inference, producing more robust …