Platelet activation plays an important role in the development of sepsis. During sepsis,
platelet activation leads to endothelial cell injury and promotes neutrophil extracellular trap …

Leukocyte migration across the endothelial barrier plays an essential role in CNS
inflammation. The migration process requires complex endothelial adhesion molecules …

In addition to their well-known role as the cellular mediators of immunity, key other roles
have been identified for neutrophils during septic shock. Importantly, neutrophils indeed play …

Megakaryocytes (MKs) are precursors to platelets, the second most abundant cells in the
peripheral circulation. However, while platelets are known to participate in immune …

From the viewpoint of the general pathology, most of the human diseases are associated
with a limited number of pathogenic processes such as inflammation, tumor growth …

Platelet transfusions can cause adverse reactions in their recipients, including transfusion-
related acute lung injury (TRALI). The pathophysiology of TRALI depends on a number of …

Introduction The treatment of burn wounds, especially deep burn wounds, remains a major
clinical challenge. Growth factors such as basic fibroblast growth factor (bFGF) and vascular …

Vitamin D deficiency and sepsis are both significant global health problems. Insufficient
vitamin D is considered to be a pathogenically relevant factor of sepsis-related deaths; …

Septicaemia is an acute inflammatory reaction in the bloodstream to the presence of
pathogen-associated molecular patterns. Whole blood stimulation assays capture endotoxin …

Melioidosis is an underreported infectious disease, caused by the Gram-negative bacterium
Burkholderia pseudomallei. Understanding the disease susceptibility and pathogenesis is …