The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

Gastrointestinal (GI) pH and temperature profiles under fasted-state conditions were
investigated in two studies with each 10 healthy human subjects using the IntelliCap® …

Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

In this review we will discuss recent advances in computational prediction of solubility in
water-based solvents. Our focus is set on recent advances in predictions of biorelevant …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

This work provides an elaborate characterization of human intestinal fluids (HIF) collected in
fasted-and fed-state conditions. HIF from 20 healthy volunteers (10 M/F) were aspirated by …

Background Biorelevant media for evaluation of dosage form performance in the
gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of …

The objective of this study was to investigate the pH-dependent solubility and dissolution of
weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized …