Programmed cell death is a basic cellular mechanism. Apoptotic-like programmed cell death
(called apoptosis in animals) occurs in both unicellular and multicellular eukaryotes, and …

Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

A cell's decision to die is controlled by a sophisticated network whose deregulation
contributes to the pathogenesis of multiple diseases including neoplastic and …

Programmed cell death (PCD) is a collective term for diverse processes causing an actively
induced, tightly controlled cellular suicide. PCD has a multitude of functions in the …

Programmed cell death is essential for the development of multicellular organisms, yet
pathways of plant programmed cell death and its regulation remain elusive. Here we report …

Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study
of oxidative stress, an event associated with cell death and severe human pathologies. This …

Metacaspases are distant relatives of animal caspases found in protozoa, fungi, and plants.
Limited experimental data exist defining their function (s), despite their discovery by …

Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and
are distantly related to metazoan caspases. Although metacaspases share structural …

The caspases are unique proteases that mediate the major morphological changes of
apoptosis and various other cellular remodeling processes. As we catalog and study the …

A canonical regulatory pathway involving the members of the Bcl-2 and caspase families
has been established to regulate developmental apoptosis in nematodes and flies …