Reactive gliosis and the multicellular response to CNS damage and disease
The CNS is prone to heterogeneous insults of diverse etiologies that elicit multifaceted
responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse …
responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse …
The glial nature of embryonic and adult neural stem cells
Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …
supportive cells with an origin very different from that of neurons. New studies have shown …
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Poor survival of human embryonic stem (hES) cells after cell dissociation is an obstacle to
research, hindering manipulations such as subcloning. Here we show that application of a …
research, hindering manipulations such as subcloning. Here we show that application of a …
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
The long-term goal of nuclear transfer or alternative reprogramming approaches is to create
patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major …
patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major …
Introduction to stem cells and regenerative medicine
Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …
Neuroplasticity in the context of motor rehabilitation after stroke
Approximately one-third of patients with stroke exhibit persistent disability after the initial
cerebrovascular episode, with motor impairments accounting for most poststroke disability …
cerebrovascular episode, with motor impairments accounting for most poststroke disability …
Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient
N Amariglio, A Hirshberg, BW Scheithauer… - PLoS …, 2009 - journals.plos.org
Background Neural stem cells are currently being investigated as potential therapies for
neurodegenerative diseases, stroke, and trauma. However, concerns have been raised over …
neurodegenerative diseases, stroke, and trauma. However, concerns have been raised over …
Paracrine mechanisms of mesenchymal stem cells in tissue repair
M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …
transdifferentiation or cell fusion was originally proposed as the principal mechanism …
In situ-forming injectable hydrogels for regenerative medicine
JA Yang, J Yeom, BW Hwang, AS Hoffman… - Progress in polymer …, 2014 - Elsevier
Regenerative medicine involves interdisciplinary biomimetic approaches for cell therapy
and tissue regeneration, employing the triad of cells, signals, and/or scaffolds. Remarkably …
and tissue regeneration, employing the triad of cells, signals, and/or scaffolds. Remarkably …
A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke
We previously evaluated the short-term follow-up preliminary data of mesenchymal stem
cells (MSCs) transplantation in patients with ischemic stroke. The present study was …
cells (MSCs) transplantation in patients with ischemic stroke. The present study was …