Raman spectroscopy: an emerging tool in neurodegenerative disease research and diagnosis

G Devitt, K Howard, A Mudher… - ACS chemical …, 2018 - ACS Publications
The pathogenesis underlining many neurodegenerative diseases remains incompletely
understood. The lack of effective biomarkers and disease preventative medicine demands …

Advances in Raman spectroscopy and imaging for biomedical research

S Siddhanta, AN Kuzmin, A Pliss, AS Baev… - Advances in Optics …, 2023 - opg.optica.org
Starting with a historical account of evolution in Raman spectroscopy, in this review we
provide details of the advancements that have pushed detection limits to single molecules …

Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy

M Ji, M Arbel, L Zhang, CW Freudiger, SS Hou… - Science …, 2018 - science.org
One of the key pathological features of Alzheimer's disease (AD) is the existence of
extracellular deposition of amyloid plaques formed with misfolded amyloid-β (Aβ). The …

Mechanisms of Biomolecular Self‐Assembly Investigated Through In Situ Observations of Structures and Dynamics

SY Schmid, K Lachowski, HT Chiang… - Angewandte Chemie …, 2023 - Wiley Online Library
Biomolecular self‐assembly of hierarchical materials is a precise and adaptable bottom‐up
approach to synthesizing across scales with considerable energy, health, environment …

Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer's disease

A Cornejo, F Aguilar Sandoval… - Journal of enzyme …, 2017 - Taylor & Francis
Alzheimer's disease is a common tauopathy where fibril formation and aggregates are the
hallmark of the disease. Efforts targeting amyloid-β plaques have succeeded to remove …

Three-dimensional ordered Ag/ZnO/Si hierarchical nanoflower arrays for spatially uniform and ultrasensitive SERS detection

S Li, N Zhang, N Zhang, D Lin, X Hu, X Yang - Sensors and Actuators B …, 2020 - Elsevier
Surface-enhanced Raman scattering (SERS) is a powerful analytic tool that can provide
information of molecular structures and composition of analytes. The application of SERS for …

Surface-enhanced Raman spectroscopy of tears: toward a diagnostic tool for neurodegenerative disease identification

G Cennamo, D Montorio, VB Morra… - … of biomedical optics, 2020 - spiedigitallibrary.org
Significance: A noninvasive method based on surface-enhanced Raman spectroscopy
(SERS) of tears was proposed as a support for diagnosing neurodegenerative pathologies …

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes

T Bhardwaj, K Gadhave, SK Kapuganti… - Nature …, 2023 - nature.com
The phenomenon of protein aggregation is associated with a wide range of human
diseases. Our knowledge of the aggregation behaviour of viral proteins, however, is still …

Identification of amyloid beta in small extracellular vesicles via Raman spectroscopy

M Imanbekova, S Suarasan, T Rojalin… - Nanoscale …, 2021 - pubs.rsc.org
One of the hallmarks of Alzheimer's disease (AD) pathogenesis is believed to be the
production and deposition of amyloid-beta (Aβ) peptide into extracellular plaques. Existing …

Engaging with Raman spectroscopy to investigate antibody aggregation

I Ettah, L Ashton - Antibodies, 2018 - mdpi.com
In the last decade, a number of studies have successfully demonstrated Raman
spectroscopy as an emerging analytical technique for monitoring antibody aggregation …