Maintenance of telomeres by the enzyme telomerase is essential for genomic stability and
cell viability in ciliates, vertebrates and yeast. The minimal components of telomerase …

We use alternating-laser excitation to achieve fluorescence-aided molecule sorting (FAMS)
and enable simultaneous analysis of biomolecular structure and interactions at the level of …

Dyskeratosis congenita (DC) is a rare inherited multi-system disorder. Although DC is
classically characterized by mucocutaneous features, the vast majority of patients develop …

The Polycomb PRC1 plays essential roles in development and disease pathogenesis.
Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins …

Telomerase contains a large RNA subunit, TER, and a protein catalytic subunit, TERT.
Whether telomerase functions as a monomer or dimer has been a matter of debate. Here we …

Dyskeratosis congenita (DC) is a rare bone marrow failure syndrome that displays marked
clinical and genetic heterogeneity. The identification of dyskeratosis congenita gene 1 …

Mutations in TERC, encoding the RNA component of telomerase, have been found in
autosomal dominant dyskeratosis congenita (DC) and aplastic anemia (AA). Several …

We investigate the structure formed by the first 18-nt of the 5′-terminal region of the human
telomerase RNA (hTERC or hTR) using gel electrophoresis and UV, CD, and NMR …

Single-molecule fluorescence spectroscopy is a powerful method to observe real time
movements of individual biological molecules while they are functioning without the need for …

Telomerase extends chromosome ends by copying a short template sequence within its
intrinsic RNA component. Telomerase RNA (TR) from different groups of species varies …