• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Angina pectoris may arise from obstructive coronary artery disease (CAD) or in the absence
of significant CAD (ischemia with nonobstructed coronary arteries [INOCA]). Therapeutic …

Since the 2009 publication of the stress echocardiography expert consensus of the
European Association of Echocardiography, and after the 2016 advice of the American …

Coronary artery disease (CAD) covers a wide spectrum from persons who are asymptomatic
to those presenting with acute coronary syndromes (ACS) and sudden cardiac death …

Objective We recently demonstrated that treatment with sodium-glucose cotransporter-2
inhibitors (SGLT-2i) leads to an increase in myocardial flow reserve in patients with type 2 …

Background Coronary flow reserve (CFR) and microvascular resistance reserve (MRR) are
physiological parameters to assess coronary microvascular dysfunction. CFR and MRR can …

Hypertensive heart disease (HHD) can no longer be considered as the beneficial adaptive
result of the hypertrophy of cardiomyocytes in response to pressure overload leading to the …

The major functions of the arterial system are to “efficiently deliver blood to the peripheral
organs and maintain vascular homeostasis”. Both the endothelial and medial layer …

After myocardial infarction (MI), patients with type 2 diabetes have an increased rate of
adverse outcomes, compared to patients without. Diabetes confers a 1.5–2-fold increase in …

Background It remains unknown whether the presence of coronary microcirculatory
dysfunction (CMD) correlates with its equivalent condition in the brain, cerebral small vessel …