Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma
Background Metabolism reprogramming plays a vital role in glioblastoma (GBM)
progression and recurrence by producing enough energy for highly proliferating tumor cells …
progression and recurrence by producing enough energy for highly proliferating tumor cells …
NDUFA12 As a functional target of the anticancer compound ertredin in human hepatoma cells as revealed by label-free chemical proteomics
SI Park, SM Cho, S Atsumi, M Kawada… - Journal of Proteome …, 2023 - ACS Publications
Many attempts have been made to develop new agents that target EGFR mutants or
regulate downstream factors in various cancers. Cell-based screening showed that a natural …
regulate downstream factors in various cancers. Cell-based screening showed that a natural …
N6‐isopentenyladenosine inhibits aerobic glycolysis in glioblastoma cells by targeting PKM2 expression and activity
Glioblastoma (GBM) is a primary tumor in the central nervous system with poor prognosis. It
exhibits elevated glucose uptake and lactate production. This metabolic state of aerobic …
exhibits elevated glucose uptake and lactate production. This metabolic state of aerobic …