Adaptive deep brain stimulation: From experimental evidence toward practical implementation
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …
an unprecedented temporal precision for neurological disorders. This has the potential to …
Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
Neural signatures of hyperdirect pathway activity in Parkinson's disease
Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …
Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication
Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …
Insights and opportunities for deep brain stimulation as a brain circuit intervention
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …
the dynamic circuit architecture of brain disorders. This Review illustrates our current …
Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
Reset of hippocampal–prefrontal circuitry facilitates learning
The ability to rapidly adapt to novel situations is essential for survival, and this flexibility is
impaired in many neuropsychiatric disorders. Thus, understanding whether and how novelty …
impaired in many neuropsychiatric disorders. Thus, understanding whether and how novelty …
[HTML][HTML] Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients
Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
Debugging adaptive deep brain stimulation for Parkinson's disease
Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease.
In adaptive DBS, stimulation is titrated according to feedback about clinical state and …
In adaptive DBS, stimulation is titrated according to feedback about clinical state and …