Cells exhibit morphological and molecular asymmetries that are broadly categorized as cell
polarity. The cell polarity established in early embryos prefigures the macroscopic …

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during early development. In this review, we discuss processes that set up the embryonic …

The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical protein kinase
C (aPKC) form a core unit of the PAR protein network, which plays a central role in …

In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR)
polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of …

PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and
enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They …

A hallmark of polarized cells is the segregation of the PAR polarity regulators into
asymmetric domains at the cell cortex,. Antagonistic interactions involving two conserved …

Cell polarity networks are defined by quantitative features of their constituent feedback
circuits, which must be tuned to enable robust and stable polarization, while also ensuring …

How cells form global, self-organized structures using genetically encoded molecular rules
remains elusive. Here, we take a synthetic biology approach to investigate the design …

Cell polarity is essential for cells to divide asymmetrically, form spatially restricted
subcellular structures and participate in three-dimensional multicellular organization. PAR …

Cell polarization enables zygotes to acquire spatial asymmetry, which in turn patterns
cellular and tissue axes during development. Local modification in the actomyosin …