Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

The state of the intestinal environment can have profound effects on the activity of the central
nervous system through the physiological contributions of the microbiota, regulation of …

Although some signs of inflammation have been reported previously in patients with myalgic
encephalomyelitis or chronic fatigue syndrome (ME/CFS), the data are limited and …

Chimeric antigen receptor (CAR) T-cell immunotherapy has revolutionized the treatment of
refractory leukemias and lymphomas, but is associated with significant toxicities, namely …

One in three people will be diagnosed with cancer during their lifetime. The community of
cancer patients is growing, and several common cancers are becoming increasingly …

Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …

Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary new form of
immunotherapy for the treatment of hematologic malignancies. The two primary toxicities …

Astrocyte dysfunction has previously been linked to multiple neurodegenerative disorders
including Parkinson's disease (PD). Among their many roles, astrocytes are mediators of the …

Cognitive impairment is a debilitating side effect experienced by patients with cancer treated
with systemically administered anticancer therapies. With around 19.3 million new cases of …

Doxorubicin is one of the most effective chemotherapeutic agents used for cancer treatment,
but it causes systemic inflammation and serious multiorgan side effects in many patients. In …