Diagnostic biomarkers for active tuberculosis: progress and challenges

BMF Nogueira, S Krishnan… - EMBO Molecular …, 2022 - embopress.org
Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious
agent, despite being preventable and curable. Early and accurate diagnosis of active TB is …

Point-of-care diagnostic tests for tuberculosis disease

JM Hong, H Lee, NV Menon, CT Lim, LP Lee… - Science translational …, 2022 - science.org
Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs)
facilitate early detection, immediate treatment, and reduced transmission of TB disease. This …

A prospective multicentre diagnostic accuracy study for the Truenat tuberculosis assays

A Penn-Nicholson, SN Gomathi… - European …, 2021 - publications.ersnet.org
Background Bringing reliable and accurate tuberculosis (TB) diagnosis closer to patients is
a key priority for global TB control. Molbio Diagnostics have developed the Truenat point-of …

Diagnostic accuracy of the truenat MTB plus assay and comparison with the Xpert MTB/RIF assay to detect tuberculosis among hospital outpatients in Cameroon

YR Ngangue, C Mbuli, A Neh, E Nshom… - Journal of Clinical …, 2022 - journals.asm.org
ABSTRACT The Truenat MTB Plus assay is a rapid molecular test that has been
recommended by the World Health Organization since 2020 as an initial test to detect …

Multicomponent strategy with decentralised molecular testing for tuberculosis in Uganda: a cost and cost-effectiveness analysis

RR Thompson, T Nalugwa, D Oyuku… - The Lancet Global …, 2023 - thelancet.com
Background Decentralised molecular testing for tuberculosis could reduce missed
diagnoses and losses to follow-up in high-burden settings. The aim of this study was to …

Health economic evidence of point-of-care testing: a systematic review

D Lingervelder, H Koffijberg, R Kusters… - PharmacoEconomics …, 2021 - Springer
Objective Point-of-care testing (POCT) has become an essential diagnostic technology for
optimal patient care. Its implementation, however, still falls behind. This paper reviews the …

Comparative analysis of truenat™ MTB plus and xpert® ultra in diagnosing tuberculous meningitis

K Sharma, M Sharma, M Modi, N Singla… - … of Tuberculosis and …, 2021 - ingentaconnect.com
BACKGROUND: Diagnostic delay and drug resistance not only worsen the outcomes of
tuberculous meningitis (TBM), but are also important impediments to TB elimination efforts …

Advanced HIV disease: A review of diagnostic and prophylactic strategies

A Lehman, J Ellis, E Nalintya, NC Bahr, A Loyse… - HIV …, 2023 - Wiley Online Library
Background Despite expanded access to antiretroviral therapy (ART) and the rollout of the
World Health Organization's (WHO)'test‐and‐treat'strategy, the proportion of people with HIV …

Expedited diagnosis of pediatric tuberculosis using Truenat MTB-Rif Dx and GeneXpert MTB/RIF

UB Singh, M Singh, S Sharma, N Mahajan, K Bala… - Scientific Reports, 2023 - nature.com
Rapid, cost-effective, and sensitive diagnostic assays are essential for global tuberculosis
(TB) control, especially in high TB burden, resource-limited settings. The current study was …

Finding the missed millions: innovations to bring tuberculosis diagnosis closer to key populations

RL Byrne, T Wingfield, ER Adams, S Banu… - BMC Global and Public …, 2024 - Springer
Current strategies to promptly, effectively, and equitably screen people with tuberculosis
(TB) and link them to diagnosis and care are insufficient; new approaches are required to …