R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …

Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …

Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated
and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box …

CTCF is a critical regulator of genome architecture and gene expression that binds
thousands of sites on chromatin. CTCF genomic localization is controlled by the recognition …

Transcription and replication both require large macromolecular complexes to act on a DNA
template, yet these machineries cannot simultaneously act on the same DNA sequence …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …

DEAD-box RNA helicases are important regulators of RNA metabolism and have been
implicated in the development of cancer. Interestingly, these helicases constitute a major …

R loops occur frequently in genomes and contribute to fundamental biological processes at
multiple levels. Consequently, understanding the molecular and cellular biology of R loops …