The hypocretin (orexin) system: from a neural circuitry perspective
Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region
known to orchestrate diverse functions including sleep, reward processing, food intake …
known to orchestrate diverse functions including sleep, reward processing, food intake …
Neuronal networks in hypertension: recent advances
Neurogenic hypertension is associated with excessive sympathetic nerve activity to the
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …
Targeting orexin receptors for the treatment of insomnia: from physiological mechanisms to current clinical evidence and recommendations
After a detailed description of orexins and their roles in sleep and other medical disorders,
we discuss here the current clinical evidence on the effects of dual (DORAs) or selective …
we discuss here the current clinical evidence on the effects of dual (DORAs) or selective …
Prefrontal cortex regulates chronic stress‐induced cardiovascular susceptibility
Background The medial prefrontal cortex is necessary for appropriate appraisal of stressful
information, as well as coordinating visceral and behavioral processes. However, prolonged …
information, as well as coordinating visceral and behavioral processes. However, prolonged …
Orexin, sleep, sympathetic neural activity, and cardiovascular function
Inadequate sleep duration and quality are associated with reduced cardiovascular health
and increased mortality. Experimental evidence points to the sympathetic nervous system as …
and increased mortality. Experimental evidence points to the sympathetic nervous system as …
[HTML][HTML] Machine learning models to predict ligand binding affinity for the orexin 1 receptor
VY Zhang, SL O'Connor, WJ Welsh… - Artificial intelligence …, 2024 - Elsevier
The orexin 1 receptor (OX1R) is a G-protein coupled receptor that regulates a variety of
physiological processes through interactions with the neuropeptides orexin A and B …
physiological processes through interactions with the neuropeptides orexin A and B …
Orexin Facilitates the Peripheral Chemoreflex via Corticotropin-Releasing Hormone Neurons Projecting to the Nucleus of the Solitary Tract
We previously showed that orexin neurons are activated by hypoxia and facilitate the
peripheral chemoreflex (PCR)-mediated hypoxic ventilatory response (HVR), mostly by …
peripheral chemoreflex (PCR)-mediated hypoxic ventilatory response (HVR), mostly by …
Activation of orexin system stimulates CaMKII expression
Hyperactivity of the orexin system within the paraventricular nucleus (PVN) has been shown
to contribute to increased sympathetic nerve activity (SNA) and blood pressure (BP) in …
to contribute to increased sympathetic nerve activity (SNA) and blood pressure (BP) in …
Orexin facilitates the ventilatory and behavioral responses of rats to hypoxia
Orexin neurons are sensitive to CO2 and contribute to cardiorespiratory homeostasis as well
as sensorimotor control. Whether orexin facilitates respiratory and behavioral responses to …
as sensorimotor control. Whether orexin facilitates respiratory and behavioral responses to …
Roles of central orexinergic system on cardiovascular function and acupuncture on intervention of cardiovascular risk: orexinergic system mediate the role of …
HR Gao, ZJ Wu, SB Wu, HY Gao, J Wang, JL Zhang… - Neuropeptides, 2021 - Elsevier
Central orexinergic system contributes to the regulation of cardiovascular function.
Orexinergic neurons receiving projections of nerve fibers from multiple structures of brain …
Orexinergic neurons receiving projections of nerve fibers from multiple structures of brain …