Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

This review focuses on the role and underlying mechanisms of mitotic catastrophe (MC) in
the regulation of drug resistance in hepatocellular carcinoma (HCC). HCC is one of the …

Oncogene amplification on extrachromosomal DNA (ecDNA) is a pervasive driver event in
cancer, yet our understanding of how ecDNA forms is limited. In this study, we couple a …

Osteosarcoma is the most common primary cancer of the bone, with a peak incidence in
children and young adults. Using multi-region whole-genome sequencing, we find that …

Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes
trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks …

Telomeres in epithelial tumours are usually maintained by telomerase, however, in the
breast cancer MDA-MB-231 cell line, polyploid cells, induced by doxorubicin (DOX) were …