Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction
between host‐specific genetic background and multiple risk factors. Globally, CCA …

Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …

Background & Aims Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer,
whose incidence and related mortality is increasing. This study investigates the clinical …

CUP accounts for< 5% of cancers but, because of its high mortality rate, its relative
contribution to cancer deaths is higher. 1 The incidence of CUP has been declining …

Background Despite improvements in multidisciplinary management, patients with biliary
tract cancer have a poor outcome. Only 20% of patients are eligible for surgical resection …

Background & Aims Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with
high aggressiveness and extremely poor prognosis. The role of circular RNAs (circRNAs) in …

Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features
of cholangiocyte differentiation: cholangiocarcinomas are categorized according to …

Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

In contrast to most other malignancies, hepatocellular carcinoma (HCC), which accounts for
approximately 90% of primary liver cancers, arises almost exclusively in the setting of …