Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

1. Introduction 292. Landmarks in NMR of macromolecules 322.1 Protein structures and
methods development 322.1. 1 Sequential assignment method 322.1. 2 Triple-resonance …

G protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex
structure poses challenges for effective drug design. Nanobodies, or single-domain …

The processes of genome replication and transcription of SARS-CoV-2 represent important
targets for viral inhibition. Betacoronaviral nucleoprotein (N) is a highly dynamic cofactor of …

The sensitivities of a number of gradient and nongradient versions of triple-resonance
experiments are compared by quantitating the signal-to-noise ratios in spectra recorded on …

Abstract The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through
activation of Wiskott–Aldrich syndrome protein (WASP) family members. Activation relieves …

New pulse schemes for recording intermolecular NOEs in a molecular complex consisting of
15N, 13C labeled and unlabeled components are presented. The pulse sequences select …

MLKL is crucial for necroptosis, permeabilizing membranes through its N-terminal region
upon phosphorylation of its kinase-like domain by RIP3. However, the mechanism …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique that can be used
to investigate the structure, dynamics, and chemical kinetics of a wide range of biochemical …

Synaptotagmin 1 probably functions as a Ca 2+ sensor in neurotransmitter release via its
two C 2-domains, but no common Ca 2+-dependent activity that could underlie a …