Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Sphingolipids are comprised of a backbone sphingoid base that may be phosphorylated,
acylated, glycosylated, bridged to various headgroups through phosphodiester linkages, or …

Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …

In mammals and Saccharomyces cerevisiae, sphingolipids have been a subject of intensive
research triggered by the interest in their structural diversity and in mammalian …

Sphingolipid synthesis involves a highly conserved biosynthetic pathway that produces
fundamental precursors of complex sphingolipids. The final reaction involves the insertion of …

Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids
differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently …

This review is focused on the formation of lateral domains in model bilayer membranes, with
an emphasis on sphingolipids and their interaction with cholesterol. Sphingolipids in …

Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and
function of these EVs remain unclear. We found that oxidative stress induced by H2O2 in …

Abstract Dihydroceramide desaturase 1 (DEGS1) converts dihydroceramide (dhCer) to
ceramide (Cer) by inserting a C4-C5 trans (∆ 4E) double bond into the sphingoid backbone …

A recently cloned cDNA from sunflower codes for a fusion protein composed of an N-
terminal cytochromeb 5 and a domain similar to membrane-bound acyl lipid desaturases …