Cancer stem cells (CSCs) are broadly considered immature, multipotent, tumorigenic cells
within the tumor mass, endowed with the ability to self-renew and escape immune control …

Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine via its
ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only …

Newly discovered anti-cancer immunotherapies, such as immune checkpoint inhibitors and
chimeric antigen receptor T cells, focus on spurring the anti-tumor effector T cell (Teff) …

Cancer stem cells (CSC) are rare immortal cells within a tumor that are able to initiate tumor
progression, development, and resistance. Advances studies show that, like normal stem …

Simple Summary Tumor necrosis factor (TNF) and its closely related cytokine, lymphotoxin
alpha (LTα), are part of the TNF superfamily and exert their functions via both overlap** …

Recent studies have highlighted important roles for long noncoding RNAs (lncRNAs) during
the complex process of carcinogenesis. H19 is an example of an lncRNA that can function …

Human studies, critical for develo** new diagnostics and therapeutics, are limited by
ethical and logistical issues, and preclinical animal studies are often poor predictors of …

Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed in various tumor cells and
some immune cells, such as regulatory T cells and myeloid-derived suppressing cells …

Lung carcinoma is the leading cause of cancer-related death worldwide, and among this
cancer, non-small cell lung carcinoma (NSCLC) comprises the majority of cases …

Human T regulatory cells (T regs) express high levels of TNF receptor 2 (TNFR2). Ligation of
TNFR2 with TNF, which can recognise both TNFR1 and TNFR2, or with a TNFR2-selective …