TRPV1-targeted drugs in development for human pain conditions

M Iftinca, M Defaye, C Altier - Drugs, 2021 - Springer
The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

[HTML][HTML] Plant-derivatives small molecules with antibacterial activity

S Alibi, D Crespo, J Navas - Antibiotics, 2021 - mdpi.com
The vegetal world constitutes the main factory of chemical products, in particular secondary
metabolites like phenols, phenolic acids, terpenoids, and alkaloids. Many of these …

The Genus Capsicum: A Review of Bioactive Properties of Its Polyphenolic and Capsaicinoid Composition

R Alonso-Villegas, RM González-Amaro… - Molecules, 2023 - mdpi.com
Chili is one of the world's most widely used horticultural products. Many dishes around the
world are prepared using this fruit. The chili belongs to the genus Capsicum and is part of …

Capsaicin and gut microbiota in health and disease

AE Rosca, MI Iesanu, CDM Zahiu, SE Voiculescu… - Molecules, 2020 - mdpi.com
Capsaicin is a widespread spice known for its analgesic qualities. Although a
comprehensive body of evidence suggests pleiotropic benefits of capsaicin, including anti …

[HTML][HTML] Personalized nutrition in the management of female infertility: new insights on chronic low-grade inflammation

G Fabozzi, G Verdone, M Allori, D Cimadomo… - Nutrients, 2022 - mdpi.com
Increasing evidence on the significance of nutrition in reproduction is emerging from both
animal and human studies, suggesting a mutual association between nutrition and female …

Mechanism investigation and experiment validation of capsaicin on uterine corpus endometrial carcinoma

Z Lin, X Sui, W Jiao, C Chen, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Background: Using bioinformatics analysis and experimental operations, we intend to
analyze the potential mechanism of action of capsaicin target gene GATA1 in the treatment …

Capsaicin: A two-decade systematic review of global research output and recent advances against human cancer

TL Adetunji, F Olawale, C Olisah, AE Adetunji… - Frontiers in …, 2022 - frontiersin.org
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products
in the genus Capsicum. Due to its numerous biological effects, there has been extensive …

Novel therapeutic hybrid systems using hydrogels and nanotechnology: a focus on nanoemulgels for the treatment of skin diseases

K Sghier, M Mur, F Veiga, AC Paiva-Santos, PC Pires - Gels, 2024 - mdpi.com
Topical and transdermal drug delivery are advantageous administration routes, especially
when treating diseases and conditions with a skin etiology. Nevertheless, conventional …

Encapsulation of hydrophobic capsaicin within the aqueous phase of water-in-oil high internal phase emulsions: Controlled release, reduced irritation, and enhanced …

X Wu, N Xu, C Cheng, DJ McClements, X Chen, L Zou… - Food …, 2022 - Elsevier
Capsaicin (CAP) is a hydrophobic substance with various physiological effects in chili
peppers that is responsible for their perceived heat. Nonetheless, its application as a …

Capsicum Waste as a Sustainable Source of Capsaicinoids for Metabolic Diseases

M Yasin, L Li, M Donovan-Mak, ZH Chen, SK Panchal - Foods, 2023 - mdpi.com
Capsaicinoids are pungent alkaloid compounds enriched with antioxidants, anti-microbial,
anti-inflammatory, analgesics, anti-carcinogenic, anti-obesity and anti-diabetic properties …