Spatial navigation deficits—overlooked cognitive marker for preclinical Alzheimer disease?

G Coughlan, J Laczó, J Hort, AM Minihane… - Nature Reviews …, 2018 - nature.com
Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify
preclinical individuals and target potentially disease-modifying therapies towards them …

Rethinking the role of the angular gyrus in remembering the past and imagining the future: the contextual integration model

S Ramanan, O Piguet, M Irish - The Neuroscientist, 2018 - journals.sagepub.com
Despite consistent activation on tasks of episodic memory, the precise contribution of the left
angular gyrus (AG) to mnemonic functions remains vigorously debated. Mounting evidence …

Left dorsolateral prefrontal cortex supports context-dependent prioritisation of off-task thought

A Turnbull, HT Wang, C Murphy, NSP Ho… - Nature …, 2019 - nature.com
When environments lack compelling goals, humans often let their minds wander to thoughts
with greater personal relevance; however, we currently do not understand how this context …

The neural correlates of ongoing conscious thought

J Smallwood, A Turnbull, H Wang, NSP Ho, GL Poerio… - Iscience, 2021 - cell.com
A core goal in cognitive neuroscience is identifying the physical substrates of the patterns of
thought that occupy our daily lives. Contemporary views suggest that the landscape of …

[HTML][HTML] Can visuospatial measures improve the diagnosis of Alzheimer's disease?

S Salimi, M Irish, D Foxe, JR Hodges, O Piguet… - Alzheimer's & Dementia …, 2018 - Elsevier
Introduction Overlap** and evolving symptoms lead to ambiguity in the diagnosis of
dementia. Visuospatial function relies on parietal lobe function, which may be affected in the …

Mental imagery in psychiatry: conceptual & clinical implications

JL Ji, DJ Kavanagh, EA Holmes, C MacLeod… - CNS …, 2019 - cambridge.org
Mental imagery refers to the experience of perception in the absence of external sensory
input. Deficits in the ability to generate mental imagery or to distinguish it from actual sensory …

The precuneus and hippocampus contribute to individual differences in the unfolding of spatial representations during episodic autobiographical memory

M Hebscher, B Levine, A Gilboa - Neuropsychologia, 2018 - Elsevier
Spatial information is a central aspect of episodic autobiographical memory (EAM). Space-
based theories of memory, including cognitive map and scene construction models, posit …

Autobiographical memory in dementia syndromes—An integrative review

M Irish - Wiley Interdisciplinary Reviews: Cognitive Science, 2023 - Wiley Online Library
Autobiographical memory represents a defining feature of human cognition, enabling us to
vividly re‐experience salient events from the personal past. By mentally traversing different …

Disease-specific patterns of cortical and subcortical degeneration in a longitudinal study of Alzheimer's disease and behavioural-variant frontotemporal dementia

R Landin-Romero, F Kumfor, CE Leyton, M Irish… - Neuroimage, 2017 - Elsevier
Abstract Background Clinical differentiation between Alzheimer's disease (AD) and
behavioural-variant frontotemporal dementia (bvFTD) is challenging due to overlap** …

Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration

C O'Callaghan, JM Shine, JR Hodges… - Proceedings of the …, 2019 - National Acad Sciences
Mind wandering represents the human capacity for internally focused thought and relies
upon the brain's default network and its interactions with attentional networks. Studies have …