Systematic review and meta-analysis of the magnitude of structural, clinical, and physician and patient barriers to cancer clinical trial participation

JM Unger, R Vaidya, DL Hershman… - JNCI: Journal of the …, 2019 - academic.oup.com
Background Barriers to cancer clinical trial participation have been the subject of frequent
study, but the rate of trial participation has not changed substantially over time. Studies often …

Enrollment of racial minorities in clinical trials: old problem assumes new urgency in the age of immunotherapy.

B Nazha, M Mishra, R Pentz… - American Society of …, 2019 - europepmc.org
Minority US populations are underrepresented in cancer clinical trials. This review appraises
the impact of the disparity in clinical trial participation by minority patients in the current era …

Representation and extrapolation: evidence from clinical trials

M Alsan, M Durvasula, H Gupta… - The quarterly journal …, 2024 - academic.oup.com
This article examines the consequences and causes of low enrollment of Black patients in
clinical trials. We develop a simple model of similarity-based extrapolation that predicts that …

Industry involvement and transparency in the most cited clinical trials, 2019-2022

LM Siena, L Papamanolis, MJ Siebert… - JAMA Network …, 2023 - jamanetwork.com
Importance Industry involvement is prominent in influential clinical trials, and commitments to
transparency of trials are highly variable. Objective To evaluate the modes of industry …

Patient and public involvement in the design of clinical trials: an overview of systematic reviews

A Price, L Albarqouni, JO Kirkpatrick… - Journal of evaluation …, 2018 - Wiley Online Library
Background Funders encourage lay‐volunteer inclusion in research. There are controversy
and resistance, given concerns of role confusion, exploratory methods, and limited evidence …

A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

D Herrera-Perez, A Haslam, T Crain, J Gill… - Elife, 2019 - elifesciences.org
The ability to identify medical reversals and other low-value medical practices is an essential
prerequisite for efforts to reduce spending on such practices. Through an analysis of more …

Diversity of enrollment in prostate cancer clinical trials: current status and future directions

EM Rencsok, LA Bazzi, RR McKay, FW Huang… - … Biomarkers & Prevention, 2020 - AACR
Background: Although there are considerable racial and ethnic disparities in prostate cancer
incidence and mortality in the United States and globally, clinical trials often do not reflect …

Consent document translation expense hinders inclusive clinical trial enrolment

MA Velez, BA Glenn, M Garcia-Jimenez, AL Cummings… - Nature, 2023 - nature.com
Patients from historically under-represented racial and ethnic groups are enrolled in cancer
clinical trials at disproportionately low rates in the USA,–. As these patients often have …

The promises and pitfalls of sex difference research

LAM Galea, E Choleris, AYK Albert… - Frontiers in …, 2020 - Elsevier
Abstract Funding agencies in North America and Europe are recognizing the importance of
the integration of sex differences into basic and clinical research. Although these mandates …

[HTML][HTML] Metrics, baseline scores, and a tool to improve sponsor performance on clinical trial diversity: retrospective cross sectional study

T Varma, M Mello, JS Ross, C Gross, J Miller - BMJ medicine, 2023 - ncbi.nlm.nih.gov
Metrics, baseline scores, and a tool to improve sponsor performance on clinical trial diversity:
retrospective cross sectional study - PMC Back to Top Skip to main content NIH NLM Logo …