[HTML][HTML] Oriented immobilization of antibodies onto sensing platforms-A critical review

S Gao, JM Guisán, J Rocha-Martin - Analytica chimica acta, 2022 - Elsevier
The immunosensor has been proven a versatile tool to detect various analytes, such as food
contaminants, pathogenic bacteria, antibiotics and biomarkers related to cancer. To fabricate …

Considerations for the design of antibody-based therapeutics

DR Goulet, WM Atkins - Journal of pharmaceutical sciences, 2020 - Elsevier
Antibody-based proteins have become an important class of biologic therapeutics, due in
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …

Gold Nanoparticle-Coated Starch Magnetic Beads for the Separation, Concentration, and SERS-Based Detection of E. coli O157:H7

SM You, K Luo, JY Jung, KB Jeong… - … applied materials & …, 2020 - ACS Publications
Here, we report gold nanoparticle-coated starch magnetic beads (AuNP@ SMBs) that were
prepared by in situ synthesis of AuNPs on the surface of SMBs. Upon functionalization of the …

Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics

H Mukai, K Ogawa, N Kato, S Kawakami - Drug metabolism and …, 2022 - Elsevier
Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics,
including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease …

Determination of the protein content of complex samples by aromatic amino acid analysis, liquid chromatography-UV absorbance, and colorimetry

K Reinmuth-Selzle, T Tchipilov, AT Backes… - Analytical and …, 2022 - Springer
Fast and accurate determination of the protein content of a sample is an important and non-
trivial task of many biochemical, biomedical, food chemical, pharmaceutical, and …

[HTML][HTML] Biofunctionalization of multiplexed silicon photonic biosensors

LS Puumala, SM Grist, JM Morales, JR Bickford… - Biosensors, 2022 - mdpi.com
Silicon photonic (SiP) sensors offer a promising platform for robust and low-cost
decentralized diagnostics due to their high scalability, low limit of detection, and ability to …

AJICAP: affinity peptide mediated regiodivergent functionalization of native antibodies

K Yamada, N Shikida, K Shimbo, Y Ito… - Angewandte …, 2019 - Wiley Online Library
The need for atom‐precise biomolecule modification, and particularly the irreversible
formation of covalent bonds to specific amino acids in proteins, has become an essential …

Immunoglobulin G structure and rheumatoid factor epitopes

SL Maibom-Thomsen, NH Trier, BE Holm, KB Hansen… - PLoS …, 2019 - journals.plos.org
Antibodies are important for immunity and exist in several classes (IgM, IgD, IgA, IgG, IgE).
They are composed of symmetric dimeric molecules with two antigen binding regions (Fab) …

Label-free immunodetection of α-synuclein by using a microfluidics coplanar electrolyte-gated organic field-effect transistor

S Ricci, S Casalini, V Parkula, M Selvaraj… - Biosensors and …, 2020 - Elsevier
The aggregation of α-synuclein is a critical event in the pathogenesis of neurological
diseases, such as Parkinson or Alzheimer. Here, we present a label-free sensor based on …

Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo

AS Obozina, EN Komedchikova, OA Kolesnikova… - Pharmaceutics, 2023 - mdpi.com
Targeted nanoparticles of different origins are considered as new-generation diagnostic and
therapeutic tools. However, there are no targeted drug formulations within the composition of …