Bile formation is a fundamental physiological process that is vital to the survival of all
vertebrates. However, little was known about the mechanisms of this secretion until after …

Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic
factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and …

Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse
reaction with complex pathomechanisms. However, it is now evident that certain forms of …

Biliary epithelial cells (BECs) are a potential source to repair the damaged liver when
hepatocyte proliferation is compromised. Promotion of BEC-to-hepatocyte …

Background & Aims Primary biliary cholangitis (PBC) is characterised by ductopenia,
ductular reaction, impairment of anion exchanger 2 (AE2) and the 'bicarbonate umbrella' …

Cholangiocytes are the epithelial cells that line the bile ducts. Along the biliary tree, two
different kinds of cholangiocytes exist: small and large cholangiocytes. Each type has …

Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract.
Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly …

This review focuses on various components of bile acid signaling in relation to
cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also …

The secretin/secretin receptor (SR) axis is up‐regulated by proliferating cholangiocytes
during cholestasis. Secretin stimulates biliary proliferation by down‐regulation of let‐7a and …

Substance P (SP) is involved in the proliferation of cholangiocytes in bile duct–ligated (BDL)
mice and human cholangiocarcinoma growth by interacting with the neurokinin‐1 receptor …