The concept of gene therapy originated in the mid twentieth century and was perceived as a
revolutionary technology with the promise to cure almost any disease of which the molecular …

Neurological disorders affecting the central nervous system (CNS) are still incompletely
understood. Many of these disorders lack a cure and are seeking more specific and effective …

Recent reports demonstrate that somatic mouse cells can be directly converted to other
mature cell types by using combined expression of defined factors. Here we show that the …

Drug-inducible systems allowing the control of gene expression in mammalian cells are
invaluable tools for genetic research, and could also fulfill essential roles in gene-and cell …

We have developed an efficient approach to generate functional induced dopaminergic (DA)
neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of …

DNA methylation contributes to the maintenance of genomic integrity in somatic cells, in part
through the silencing of transposable elements. In this study, we use CRISPR-Cas9 …

New neurons are continuously generated from neural stem cells with astrocyte properties,
which reside in close proximity to the ventricle in the postnatal and adult brain. In this study …

Chondroitinase ABC is a promising preclinical therapy that promotes functional
neuroplasticity after CNS injury by degrading extracellular matrix inhibitors. Efficient delivery …

Many neurodegenerative diseases are characterized by the presence of intracellular protein
aggregates, resulting in alterations in autophagy. However, the consequences of impaired …

The glial cell line-derived neurotrophic factor (GDNF) is a well-established trophic agent for
dopaminergic (DA) neurons in vitro and in vivo. GDNF is necessary for maintenance of …