Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating
normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in …

Uncoupling protein (UCP) 1 is an integral membrane protein that is located in the
mitochondrial inner membrane of brown adipocytes. Its physiological role is to mediate a …

Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and
breed-associated behaviors resulting from human selective pressures. To identify the …

Comparative protein modeling is increasingly gaining interest since it is of great assistance
during the rational design of mutagenesis experiments. The availability of this method, and …

We describe a new method (T-Coffee) for multiple sequence alignment that provides a
dramatic improvement in accuracy with a modest sacrifice in speed as compared to the most …

Abstract The ExPASy (the Expert Protein Analysis System) World Wide Web server
(http://www. expasy. org), is provided as a service to the life science community by a …

Abstract SWISS-MODEL (http://swissmodel. expasy. org) is a server for automated
comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of …

Not so long ago, multivariate analysis consisted solely of linear methods illustrated on small
to medium-sized data sets. Moreover, statistical computing meant primarily batch processing …

Excessive mitochondrial fission is associated with the pathology of a number of
neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could …

For several years we have been concentrating on develo** methods for large-scale
sequencing projects and the resulting software is used in many major laboratories and …