Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4‐hydroxy‐2‐nonenal

A Ayala, MF Muñoz, S Argüelles - Oxidative medicine and …, 2014 - Wiley Online Library
Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …

Advantages and disadvantages of apoptosis in the aging process

S Argüelles, A Guerrero‐Castilla… - Annals of the New …, 2019 - Wiley Online Library
Researchers cannot predict as yet how long a human being can live. Life expectancy has
been steadily increasing in the last century, but perhaps not always the quality of life in …

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

T Udagawa, Y Fujioka, M Tanaka, D Honda… - Nature …, 2015 - nature.com
Abstract FUS is an RNA/DNA-binding protein involved in multiple steps of gene expression
and is associated with amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar …

iTRAQ and PRM-based comparative proteomic profiling in gills of white shrimp Litopenaeus vannamei under copper stress

H Guo, T Chen, Z Liang, L Fan, Y Shen, D Zhou - Chemosphere, 2021 - Elsevier
Crustaceans are particularly sensitive to heavy metal pollution. Copper (Cu) is one of typical
heavy metal pollutants in aquatic ecosystems. However, limited attention has been paid on …

TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation

J Zhu, X Ao, Y Liu, S Zhou, Y Hou, Z Yan, L Zhou… - Respiratory …, 2024 - Springer
Background Although recent studies provide mechanistic understanding to the
pathogenesis of radiation induced lung injury (RILI), rare therapeutics show definitive …

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

DD Song, TT Zhang, JL Chen, YF **a, ZH Qin… - Cell death & …, 2017 - nature.com
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic
tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine …

The diphthamide modification pathway from Saccharomyces cerevisiae – revisited

R Schaffrath, W Abdel‐Fattah, R Klassen… - Molecular …, 2014 - Wiley Online Library
Diphthamide is a conserved modification in archaeal and eukaryal translation elongation
factor 2 (EF2). Its name refers to the target function for diphtheria toxin, the disease‐causing …

Complex evolutionary history of translation elongation factor 2 and diphthamide biosynthesis in archaea and parabasalids

AB Narrowe, A Spang, CW Stairs… - Genome biology and …, 2018 - academic.oup.com
Diphthamide is a modified histidine residue which is uniquely present in archaeal and
eukaryotic elongation factor 2 (EF-2), an essential GTPase responsible for catalyzing the …

Identification of Ginger (Zingiber officinale Roscoe) Reference Genes for Gene Expression Analysis

Y Lv, Y Li, X Liu, K Xu - Frontiers in Genetics, 2020 - frontiersin.org
Quantitative real-time PCR (qRT-PCR) is widely used in the detection of gene expression
level. However, there is no suitable ginger reference gene for qPCR analysis. Therefore, it is …

Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions

S Argüelles, S Camandola, RG Cutler, A Ayala… - Free Radical Biology …, 2014 - Elsevier
Abstract Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the
mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for …