[HTML][HTML] Drug resistance in liver flukes

I Fairweather, GP Brennan, REB Hanna… - International Journal for …, 2020 - Elsevier
Liver flukes include Fasciola hepatica, Fasciola gigantica, Clonorchis sinensis, Opisthorchis
spp., Fascioloides magna, Gigantocotyle explanatum and Dicrocoelium spp. The two main …

[HTML][HTML] Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor …

AC Kotze, PW Hunt, P Skuce… - International Journal for …, 2014 - Elsevier
Anthelmintic resistance has a great impact on livestock production systems worldwide, is an
emerging concern in companion animal medicine, and represents a threat to our ongoing …

Strategies to optimize the efficacy of anthelmintic drugs in ruminants

C Lanusse, C Canton, G Virkel, L Alvarez… - Trends in …, 2018 - cell.com
Anthelmintic resistance in human and animal pathogenic helminths has been spreading in
prevalence and severity. Multidrug resistance is a widespread problem in livestock animals …

Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases

MW Robinson, JP Dalton - Philosophical Transactions of …, 2009 - royalsocietypublishing.org
Zoonotic infections are among the most common on earth and are responsible for> 60 per
cent of all human infectious diseases. Some of the most important and well-known human …

Understanding triclabendazole resistance

GP Brennan, I Fairweather, A Trudgett, E Hoey… - … and molecular pathology, 2007 - Elsevier
Triclabendazole (TCBZ) has been the drug of choice to treat liver fluke infections in livestock
for> 20 years, due to its high activity against both adult and juvenile flukes. More recently, it …

Update on trematode infections in sheep

FA Rojo-Vázquez, A Meana, F Valcárcel… - Veterinary …, 2012 - Elsevier
Trematode parasites live in the liver, fore stomachs or blood vessels of a wide range of
animals and humans. Most of them have a special economic and veterinary significance …

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

NJ Beesley, K Cwiklinski, K Allen, RC Hoyle… - PLoS …, 2023 - journals.plos.org
Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …

Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?

I Fairweather - Veterinary parasitology, 2011 - Elsevier
The liver fluke remains an economically significant parasite of livestock and is emerging as
an important zoonotic infection of humans. The incidence of the disease has increased in …

Triclabendazole: new skills to unravel an old (ish) enigma

I Fairweather - Journal of helminthology, 2005 - cambridge.org
Triclabendazole was introduced in the early 1980s for the treatment of Fasciola hepatica
infections in livestock. Due to its high activity against immature flukes, it has become …

The biological significance of methionine sulfoxide stereochemistry

BC Lee, VN Gladyshev - Free Radical Biology and Medicine, 2011 - Elsevier
Methionine can be oxidized by reactive oxygen species to a mixture of two diastereomers,
methionine-S-sulfoxide and methionine-R-sulfoxide. Both free amino acid and protein …