Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder is characterized by the formation of extracellular amyloid plaques and intracellular …

Amyloid beta (Aβ) homeostasis in the brain is governed by its production and clearance
mechanisms. An imbalance in this homeostasis results in pathological accumulations of …

Background Observational studies and previous Mendelian randomization (MR) studies
have shown that genetically low 25-hydroxyvitamin D (25OHD) levels are associated with a …

Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …

Objectives To resolve the ongoing debate on the role of plasma omega-3 fatty acids in
rheumatoid arthritis (RA), we attempted to identify the association between omega-3 intake …

Background PICALM is one of the most significant susceptibility factors for Alzheimer's
disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium …

Alzheimer's disease (AD) is a highly heritable disease (with heritability up to 76%) with a
complex genetic profile of susceptibility, among which large genome-wide association …

Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D).
Osteoarthritis (OA) is a common joint disease that limits patients' physical activity, which may …

Background A recent Mendelian randomization (MR) did not support an effect of the lead
interleukin-6 receptor (IL-6 R) variant on risk of pulmonary arterial hypertension (PAH). Thus …