Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …

A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and
adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) …

Pediatric cancers often mimic fetal tissues and express proteins normally silenced
postnatally that could serve as immune targets. We developed T cells expressing chimeric …

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states.
Previous genetic studies have largely focused on insulin resistance in the fasting state …

The in vitro oxygen microenvironment profoundly affects the capacity of cell cultures to
model physiological and pathophysiological states. Cell culture is often considered to be …

Novel COVID-19 therapeutics are urgently needed. We generated a phage-displayed
human antibody VH domain library from which we identified a high-affinity VH binder ab8 …

The Omicron variant continuously evolves under the humoral immune pressure exerted by
vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

MFSD2A is a sodium-dependent lysophosphatidylcholine symporter that is responsible for
the uptake of docosahexaenoic acid into the brain,, which is crucial for the development and …

CAR T-cell therapy is well tolerated and effective in patients with Hodgkin lymphoma (HL)
and anaplastic large cell lymphoma (ALCL). However, even second-generation anti-CD30 …

Integral membrane proteins (MPs) are important drug targets across most fields of medicine,
but historically have posed a major challenge for drug discovery due to difficulties in …